TOYOTA 4A GE NO FURTHER A MYSTERY

I read on the web that when they aren't nicely synced it can result in prosperous running, backfiring and vibrations. Maybe I am wondering the incorrect way but when they wouldn't be synced then the fuel/air combination can be unique wouldn't it?On the 4AGZ consumption manifold- the #1 runner, which happens to be dog-legged, needs to be loaded and